Studies on anti-MRSA parenteral cephalosporins. III. Synthesis and antibacterial activity of 7β-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2(Z)- alkoxyimininoacetamido]-3-[(E)-2-(1-alkylimidazol{1,2-b]pyridazinium-6-y) thiovinyl]-3-cephem-4-carboxylates and relat

Article abstract of DOI:10.7164/antibiotics.54.257

In the course of our exploration for a novel cephalosporin derivative having excellent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), we modified the C-3 linked spacers of cephem derivatives bearing a 1-methylimidazo[1,