Synthesis of the central C18-C30 core of the phorboxazole natural products

DOI: 10.1016/0040-4039(96)01435-9

Source and publish data:

Tetrahedron Letters p. 6449 - 6452 (1996)

Update date:2022-08-04

Topics:

Authors:

Lee, Chi Sing

Forsyth, Craig J.

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Article abstract of DOI:10.1016/0040-4039(96)01435-9

A direct synthesis of the central C18-C30 core of the phorboxazole natural products has been developed. This involves construction of an acyclic acrylate using Paterson's (E)-enol borinate aldol methodology followed by an intramolecular hetero-Michael addition to form the central pyran ring of the natural products.

Full text of DOI:10.1016/0040-4039(96)01435-9

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