
Tetrahedron Letters p. 6449 - 6452 (1996)
Update date:2022-08-04
Topics:
Lee, Chi Sing
Forsyth, Craig J.
A direct synthesis of the central C18-C30 core of the phorboxazole natural products has been developed. This involves construction of an acyclic acrylate using Paterson's (E)-enol borinate aldol methodology followed by an intramolecular hetero-Michael addition to form the central pyran ring of the natural products.
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