Enzymatic Synthesis of Side Chain Benzyl Esters of L-α-Amino Dicarboxylic Acids

Article abstract of DOI:10.1016/S0957-4166(00)86032-2

Diesters of L-α-amino dicarboxylic acids were specifically hydrolyzed by pronase at their α carboxylic group while the corresponding D-enantiomers remained unchanged.This enabled easy obtention of side chain benzyl esters of L-α-amino dicarboxylic acids starting from both optically active and racemic dibenzyl ester derivatives. Key Words: Enzymatic Synthesis: Pronase: L-α-amino suberic acid-ω-benzyl ester; Regioselectivity; Optical Resolution.