Tetrahedron Asymmetry p. 1015 - 1018 (1992)
Update date:2022-07-29
Topics:
Pugniere, Martine
Castro, Bertrand
Domergue, Nicole
Previero, Aldo
Diesters of L-α-amino dicarboxylic acids were specifically hydrolyzed by pronase at their α carboxylic group while the corresponding D-enantiomers remained unchanged.This enabled easy obtention of side chain benzyl esters of L-α-amino dicarboxylic acids starting from both optically active and racemic dibenzyl ester derivatives. Key Words: Enzymatic Synthesis: Pronase: L-α-amino suberic acid-ω-benzyl ester; Regioselectivity; Optical Resolution.
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