Design and synthesis of gentiohexaosyl derivatives for an ANP receptor antagonist, HS-142-1

Article abstract of DOI:10.1271/bbb.60.1308

A hexaosyl fragment of the major component of lipooligosaccharide HS- 142-1, O-(3-O-caproyl-β-D-glucopyranosyl)-(1→6)-[O-(β-D-glucopyranosy l)- (1→6)-O-(3-O-caproyl-β-D-glucopyranosyl)-(1→ 6)]₂-D-glucopyranose (1), was efficiently synthesized by block synthesis. More stable analogs, O-(3-O- hexyl-B-D-glucopyranosyl)-(1→6)-[O-(B-D-glucopyranosyl)-(1→6)-O -(3-O-hexyl- β-D-glucopyranosyl)-(l→6)]₂-D-glucopyranose (4) and O-(3-O-caproyl-2,4,6- tri-O-methyl-β-D-glacopyranosyl)-(1→6)-[O(2,3,4-tri-O-methyl-β -D- glucopyranosyl)-(1→6)-O-(3-O-caproyl-2,4-di-O-methyl-β-D-glucop yranosyl)- (1→6)]₂-2,3,4-tri-O-methyl-D-glucopyranose (2), were also designed and synthesized in a similar manner.

Full text of DOI:10.1271/bbb.60.1308

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Design and Synthesis of Gentiohexaosyl Derivatives
for an ANP Receptor Antagonist, HS-142–1
Yi Qiua, Yoshiaki Nakaharaa & Tomoya Ogawaab
a The Institute of Physical and Chemical Research (RIKEN), Wako-shi, Saitama 351-01,
Japan
b Graduate School for Agriculture and Life Sciences, The University of Tokyo, Yayoi,
Bunkyo-ku, Tokyo 113, Japan
Published online: 12 Jun 2014.
To cite this article: Yi Qiu, Yoshiaki Nakahara & Tomoya Ogawa (1996) Design and Synthesis of Gentiohexaosyl Derivatives
for an ANP Receptor Antagonist, HS-142–1, Bioscience, Biotechnology, and Biochemistry, 60:8, 1308-1316, DOI: 10.1271/
bbb.60.1308
To link to this article: http://dx.doi.org/10.1271/bbb.60.1308
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