Formal substitution at both bridgeheads of a bicyclo[2.2.2]oct-5-en-2-one and its application to a synthesis of (±)-modhephene

Article abstract of DOI:10.1016/0040-4039(96)01652-8

Synthesis of a propellane sesquiterpene (±)-modhephene (23) was achieved on the basis of a novel procedure to introduce the desired alkyl groups at both bridgeheads of a bicyclo[2.2.2]oct-5-en-2-one.