Journal of the Chemical Society. Perkin transactions I p. 2221 - 2226 (1996)
Update date:2022-07-31
Topics:
Rewcastle, Gordon W.
Denny, William A.
Winters, R. Thomas
Colbry, Norman L.
Showalter, H. D. Hollis
Directed lithiation of Boc or pivaloyl derivatives of 2-substituted 5-aminopyridines with BuLi-TMEDA in diethyl ether at -10°C gave 4-lithio derivatives which were quenched with CO2 to give the analogous C-4 carboxylic acids. Hydrolysis of the protecting groups with either TFA or aqueous KOH gave 2-substituted 5-aminopyridine-4-carboxylic acids which were converted to 6-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones by reaction with formamide or, more optimally, formamidine acetate. Boc protected aminopyridines provided the best overall results, with synthesis of these derivatives best achieved by direct reaction of the aminopyridine with di-tert-butyl dicarbonate in the absence of added base.
View MoreZhejiang Quzhou Zhengbang Organosilicon Co.,ltd.
Contact:86-570-3375195
Address:No.17 Lingqing Road technology industry,Quzhou City,Zhejiang Province,China
Shandong LuZhou Amino Acid Co., Ltd
Contact:86-539-2218025
Address:yishui economic and technical development zone zhenxing south road
Contact:027-87677569
Address:Room 2203, yujingmingmen Buidling One, xiongchu Road, wuhan city, hubei province, China
SHAANXI FUJIE PHARMACEUTICAL CO.,LTD
website:http://www.fujiepharm.com
Contact:+86-29-63650906
Address:Yuanqu Yi Road, Qinghe Food Industrial Park, Sanyuan County, Shaanxi Province, China
website:http://www.greenutra.cn
Contact:0086-411-39553357
Address:No. 7-1-1802, Huizhi Garden,Ocean Square,Dalian, 116033, China
Doi:10.1039/b202715c
(2002)Doi:10.1039/b101766g
(2001)Doi:10.1021/ol016324p
(2001)Doi:10.1007/s13738-016-0929-4
(2016)Doi:10.1021/jo0103672
(2001)Doi:10.1021/ja01646a043
(1954)
