Russian Chemical Bulletin p. 1680 - 1687 (1996)
Update date:2022-08-04
Topics:
Zlotin
Sharova
Luk'yanov
N-(Aroylaminomethyl)glycine amides were synthesized by reactions of N-(aroylamino-methyl)glycine esters with ammonia. Alkaline hydrolysis of N-(amidomethyl)glycine, N-(imidomethyl)glycine, and N-(amidomethyl)phenylalanine esters afforded the corresponding N-(amidomethyl)-α-amino acids. Reactions of the last-mentioned compounds with ethyl esters of glycine, alanine, and phenylalanine in the presence of dicyclohexylcarbodiimide yielded dipeptides containing N-amidomethyl substituents.
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