Cyclic nitrone free radical traps: Isolation, identification, and synthesis of 3,3-dimethyl-3,4-dihydroisoquinolin-4-ol N-oxide, a metabolite with reduced side effects

DOI: 10.1021/jm960244n

Source and publish data:

Journal of Medicinal Chemistry p. 4997 - 5004 (1996)

Update date:2022-09-26

Topics:

Authors:

Thomas, Craig E.

Bernardelli, Patrick

Bowen, S. Marc

Chaney, Stephen F.

Friedrich, Dirk

Janowick, David A.

Jones, Bryan K.

Keeley, Frederick J.

Kehne, John H.

Ketteler, Bert

Ohlweiler, David F.

Paquette, Leo A.

Robke, David J.

Fevig, Thomas L.

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Article abstract of DOI:10.1021/jm960244n

A C-4 hydroxylated metabolite (2, 3,3-dimethyl-3,4-dihydroisoquinolin- 4-ol N-oxide) of the previously described cyclic nitrone free radical trap 1 (3,3-dimethyl-3,4-dihydroisoquinoline N-oxide, a cyclic analog of phenyl- tert-butylnitrone (PBN)) was isol

Full text of DOI:10.1021/jm960244n

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