Chemical and Pharmaceutical Bulletin p. 2061 - 2069 (1996)
Update date:2022-08-03
Topics:
Seki, Toshimi
Nakao, Tomio
Masuda, Takeshi
Hasumi, Kohichi
Gotanda, Kotaro
Ishimori, Tsutomu
Honma, Seijiro
Minami, Nobuyoshi
Shibata, Kenyu
Yasuda, Kikuo
A series of novel pyridazinone derivatives (II) having a phenoxypropanolamine moiety was synthesized. Their hypotensive and β- blocking activities were evaluated after intravenous administration of the compounds to anesthetized rats. Among them, the 5-chloro-2-cyanophenoxy derivative (29) showed the promising dual activities and was selected for further studies.
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