An NMR study of halogenated 1,4-dihydro-1-ethyl-4-oxoquinoline-3-carboxylates

Article abstract of DOI:10.1002/(SICI)1097-458X(199611)34:11<972::AID-OMR994>3.0.CO;2-9

Ethyl 1,4-dihydro-1-ethyl-4-oxoquinoline-3-carboxylate and 29 of its mono-, di-and tri-fluoro and/or -chloro derivatives were synthesized and their ¹H, ¹³C and ¹⁹F NMR spectra were recorded. ¹H, ¹³C and ¹⁹F chemical shifts, J_HH, J_FH, J_CF and J_FF coupling constants are reported. The ¹³C substituent chemical shift values of the chloro and fluoro substituents were calculated by linear multiple regression.