An efficient method for the synthesis of substituted TosMIC precursors

DOI: 10.1016/0040-4039(96)01886-2

Source and publish data:

Tetrahedron Letters p. 8113 - 8116 (1996)

Update date:2022-08-03

Topics:

Authors:

Sisko, Joseph

Mellinger, Mark

Sheldrake, Peter W.

Baine, Neil H.

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Article abstract of DOI:10.1016/0040-4039(96)01886-2

Substituted tosylmethyl isocyanides (TosMICs) are useful reagents for which no general method of preparation is available. We describe here a high-yielding method for the synthesis of substituted tosylmethyl formamides, which are readily converted to the corresponding isocyanides.

Full text of DOI:10.1016/0040-4039(96)01886-2

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Product name:Formamide, N-[2,2-dimethyl-1-[(4-methylphenyl)sulfonyl]propyl]-

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