Enantioselective reduction of ketones with borane catalyzed by cyclic β-amino alcohols prepared from proline

Article abstract of DOI:10.1016/S0957-4166(96)00443-0

New catalysts have been prepared from (S)- and (R)-proline and the asymmetric borane reduction of prochiral ketones using these catalysts has been studied. The secondary alcohols were obtained in 76-95% yield with 57-96% enantiomeric excesses.