Structure-activity relationships for macrocyclic peptidomimetic inhibitors of HIV-1 protease

DOI: 10.1016/0960-894X(96)00468-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2531 - 2536 (1996)

Update date:2022-08-05

Topics:

Authors:

Abbenante

Bergman Bergman

Brinkworth

March March

Reid Reid

Hunt Hunt

James James

Dancer Dancer

Garnham Garnham

Stoermer

Fairlie Fairlie

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0960-894X(96)00468-4

A series of appended macrocycles were synthesized and tested as inhibitors of HIV-1 protease (HIV PR). The macrocycle structurally mimics an N-terminal tripeptide component of peptide substrates. Structure-activity relationships explore steric limitations to the size and shape of the substituents and provide evidence for functional mimicry of substrate components.

Full text of DOI:10.1016/0960-894X(96)00468-4

Products guided by the article

Product name:4-{4-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-4-((S)-2-tert-butylcarbamoyl-piperidin-1-yl)-3-hydroxy-butyl]-phenoxy}-butyric acid

Cas No:185303-94-0

R&D Labs maybe for 185303-94-0

Tianjin Dongchang Fine Chemical Industry Co., Ltd.

Contact:+86-22-29894595

Address:Economic Developing Zone, Ji County, Tianjin, China
Sinonine Industry Co.,Ltd

Contact:86+21-56421993

Address:3F,BUILDING 10,NO.2889 JINKE ROAD, SHANGHAI.
Shijiazhuang Haitian Amino Acid Co., Ltd.

Contact:+86-311-88908111

Address:Shijiazhuang Hebei province,China
SuZhou Yacoo Science Co., Ltd

Contact:86-512-87182055

Address:No.128 Fangzhou Rd, Suzhou Industrial Park, China, 215125, China
Zhuhai Rundu Pharmaceutical co.,Ltd

Contact:+86-756-7630755

Address:No.6,North Airport Road,Sanzao Town,Jinwan District

Relevant to this article

An enantioselective total synthesis of (+)-cassiol

Doi:10.1016/S0040-4039(96)02191-0
(1996)
Nickel-mediated cyclobutabenzene syntheses. trans-7,8-dibromo-cyclobutabenzenes: 1 Their one-pot preparation, x-ray structure, and Diels-Alder reactions

Doi:10.1021/jo9516852
(1996)
An approach to highly functionalized dendrimers from chiral, non-racemic synthetic monomers

Doi:10.1016/0040-4039(96)01295-6
(1996)
Mixed iron-silicon-tin complexes stabilized by a phosphinoenolate bridging ligand. Crystal structure of [(OC)₃{(MeO)₃Si}-Fe{μ-Ph ₂PCH=C(O)Ph}SnBuⁿ₂]

Doi:10.1039/DT9960004365
(1996)
Design, synthesis and structure-activity relationship of a series of arginine aldehyde factor Xa inhibitors. Part 1: Structures based on the (D)- Arg-Gly-Arg tripeptide sequence

Doi:10.1016/S0960-894X(99)00582-X
(2000)
Efficient asymmetric synthesis of (R)-3-hydroxy- and alkanoyloxytetradecanoic acids and method for the determination of enantiomeric purity

Doi:10.1016/S0957-4166(96)00464-8
(1996)

Article Doi