Structure-activity relationships for macrocyclic peptidomimetic inhibitors of HIV-1 protease

DOI: 10.1016/0960-894X(96)00468-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2531 - 2536 (1996)

Update date:2022-08-05

Topics:

Authors:

Abbenante

Bergman Bergman

Brinkworth

March March

Reid Reid

Hunt Hunt

James James

Dancer Dancer

Garnham Garnham

Stoermer

Fairlie Fairlie

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0960-894X(96)00468-4

A series of appended macrocycles were synthesized and tested as inhibitors of HIV-1 protease (HIV PR). The macrocycle structurally mimics an N-terminal tripeptide component of peptide substrates. Structure-activity relationships explore steric limitations to the size and shape of the substituents and provide evidence for functional mimicry of substrate components.

Full text of DOI:10.1016/0960-894X(96)00468-4

Products guided by the article

Product name:4-{4-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-4-((S)-2-tert-butylcarbamoyl-piperidin-1-yl)-3-hydroxy-butyl]-phenoxy}-butyric acid

Cas No:185303-94-0

R&D Labs maybe for 185303-94-0

Yancheng Smiling Imp & Exp Co., Ltd.

Contact:+86-515-83173586

Address:Rm1207, BLD#03, Phoenix Plaza, Juheng Road, Yancheng, Jiangsu, P.R. China
WUXI HONOR SHINE CHEMICAL CO.,LTD

Contact:+86-510-83593312

Address:No.1699 Huishan avenue,Huishan district,Wuxi ,Jiangsu,China,214177.(Wuxi Huishan Ecomonic Develop Zone )
Shandong Jusage Technology Co.,Ltd.

Contact:86-13406130167

Address:No.20,North Ride No.9 Road, Guangrao Economic Development Zone, Shandong Province
Suzhou Jingye Medicine & Chemical Co., Ltd

Contact:+86-512-66658588

Address:No. 88, Sanlian Street, Jinfeng Road, Suzhou New District, Jiangsu Province, P. R. China
Shanghai Kangxin Chemical Co., Ltd

Contact:+86 21 60717227

Address:118,Ganbai Village,Waigang Town,Jiading District,Shanghai

Relevant to this article

An enantioselective total synthesis of (+)-cassiol

Doi:10.1016/S0040-4039(96)02191-0
(1996)
Nickel-mediated cyclobutabenzene syntheses. trans-7,8-dibromo-cyclobutabenzenes: 1 Their one-pot preparation, x-ray structure, and Diels-Alder reactions

Doi:10.1021/jo9516852
(1996)
An approach to highly functionalized dendrimers from chiral, non-racemic synthetic monomers

Doi:10.1016/0040-4039(96)01295-6
(1996)
Mixed iron-silicon-tin complexes stabilized by a phosphinoenolate bridging ligand. Crystal structure of [(OC)₃{(MeO)₃Si}-Fe{μ-Ph ₂PCH=C(O)Ph}SnBuⁿ₂]

Doi:10.1039/DT9960004365
(1996)
Design, synthesis and structure-activity relationship of a series of arginine aldehyde factor Xa inhibitors. Part 1: Structures based on the (D)- Arg-Gly-Arg tripeptide sequence

Doi:10.1016/S0960-894X(99)00582-X
(2000)
Efficient asymmetric synthesis of (R)-3-hydroxy- and alkanoyloxytetradecanoic acids and method for the determination of enantiomeric purity

Doi:10.1016/S0957-4166(96)00464-8
(1996)

Article Doi