Iodotrimethylsilane-Promoted 1,4-Addition of Copper Acetylides to α,β-Unsaturated Ketones and Aldehydes

Article abstract of DOI:10.1021/jo960393d

In the presence of iodotrimethylsilane (TMSI) and lithium iodide in tetrahydrofuran, the otherwise unreactive copper acetylides add to enones present as s-trans conformers to provide good yields of the silyl enol ethers of β-acetylido carbonyl compounds.