Organic and Biomolecular Chemistry p. 6115 - 6119 (2021)
Update date:2022-08-04
Topics:
Chen, Zhengkai
Du, Shiying
Song, Yufei
Wang, Le-Cheng
Wu, Xiao-Feng
A metal-free cascade coupling/iodoaminocyclization reaction for the rapid assembly of 2-trifluoromethyl-imidazolines has been disclosed. The transformation applies readily accessible trifluoroacetimidoyl chlorides, allylamines andN-iodosuccinimides as the starting substrates, achieving an efficient and straightforward pathway to construct diverse imidazoline derivatives. Excellent efficiency of the reaction is observed (higher than 90% isolated yield for half of the examples), and the obtained imidazoline products bearing a pendent iodomethyl group could be easily transformed into other synthetically valuable compounds.
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Doi:10.1055/s-1985-34144
(1985)Doi:10.1002/anie.200902840
(2009)Doi:10.1007/s11743-010-1205-8
(2011)Doi:10.1016/S0022-328X(00)83265-9
(1964)Doi:10.1002/1099-0690(200209)2002:18<3162::AID-EJOC3162>3.0.CO;2-H
(2002)Doi:10.1016/S0022-1139(00)82328-3
(1985)