Nitrogen and sulfur analogues of the seco-CI alkylating agent: Synthesis and cytotoxicity

Article abstract of DOI:10.1016/S0960-894X(96)00507-0

The first synthesis of seco-CI alkylating agents bearing a nitrogen or sulfur substituent in place of the oxygen at C-6 is described. In comparison with a phenol, an amino substituent confers reduced but significant cytotoxicity, even when mono- or dimethylated, while sulfur analogues are considerably less potent.