Bioorganic and Medicinal Chemistry Letters p. 2735 - 2740 (1996)
Update date:2022-08-03
Topics:
Tercel
Denny
Wilson
The first synthesis of seco-CI alkylating agents bearing a nitrogen or sulfur substituent in place of the oxygen at C-6 is described. In comparison with a phenol, an amino substituent confers reduced but significant cytotoxicity, even when mono- or dimethylated, while sulfur analogues are considerably less potent.
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