
Chemical Communications p. 2569 - 2570 (1996)
Update date:2022-08-05
Topics: Protection of the Hydroxyl Group Resolution of the Racemic Mixture Introduction of the Amino Group
Arnone, Alberto
Gestmann, Detlef
Meille, Stefano Valdo
Resnati, Giuseppe
Sidoti, Giancarlo
The copper(I) catalysed aldol reaction between methyl isocyanoacetate and (S)-3-fluoro-1-(4-methylphenyl)sulfinylacetone affords oxazoline products which, after diastereoisomer separation, give in high yields optically pure 3-fluoromethylthreonine analogues whose absolute and relative configurations have been assigned through X-ray analyses.
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Doi:10.1021/jm00308a053
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