Bioorganic and Medicinal Chemistry Letters p. 2787 - 2790 (1996)
Update date:2022-08-03
Topics:
Slater, Martin J.
Gowrie, Clare
Freeman
Short
2'-Deoxy-2'-fluoro-ribavirin has been efficiently synthesised from 2'-deoxy-2'-fluorouridine using nucleoside transferase as the key step, and evaluated for its antiviral properties in cell culture. An efficient synthesis of 3,5-di-O-p-chlorobenzoyl-2-deoxy-2-fluoro-β-D-ribofuranose is also described.
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Doi:10.1021/jo01063a613
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