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164. Hydrolytical cleavage of TAR-RNA, the trans-Activation responsive region of HIV-1, by a bis(guanidinium) catalyst attached to arginine

DOI: 10.1002/hlca.19960790719

Source and publish data:

Helvetica Chimica Acta p. 1967 - 1979 (1996)

Update date:2022-08-02

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Authors:

Kurz, KristinaKurz, Kristina

Goebel, Michael W.Goebel, Michael W.

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Article abstract of DOI:10.1002/hlca.19960790719

Guanidinium compounds imitating the bis(arginine) structural motif of staphylococcal nuclease (e.g. 3) are known to be powerful catalysts for phosphoryl transfer reactions in dipolar aprotic solvents. Compound 3 also accelerates the hydrolysis of RNA (H View More

Full text of DOI:10.1002/hlca.19960790719

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