164. Hydrolytical cleavage of TAR-RNA, the trans-Activation responsive region of HIV-1, by a bis(guanidinium) catalyst attached to arginine

Article abstract of DOI:10.1002/hlca.19960790719

Guanidinium compounds imitating the bis(arginine) structural motif of staphylococcal nuclease (e.g. 3) are known to be powerful catalysts for phosphoryl transfer reactions in dipolar aprotic solvents. Compound 3 also accelerates the hydrolysis of RNA (H