Design, synthesis and anticonvulsant activity of the potent adenosine kinase inhibitor GP3269

Article abstract of DOI:10.1080/07328319708006124

The pyrrolopyrimidine nucleoside GP3269 (12) was shown to be a potent and selective inhibitor of human adenosine kinase (IC₅₀ = 11 nM) and to exhibit anticonvulsant activity in rats after oral administration. Synthesis of GP3269 was accomplishe

Full text of DOI:10.1080/07328319708006124

This article was downloaded by: [Van Pelt and Opie Library]
On: 19 October 2014, At: 23:43
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number: 1072954 Registered
office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH, UK
Nucleosides and Nucleotides
Publication details, including instructions for authors and
subscription information:
http://www.tandfonline.com/loi/lncn19
Design, Synthesis and Anticonvulsant
Activity of the Potent Adenosine
Kinase Inhibitor GP3269
Mark D. Erion a , Bheemarao G. Ugarkar a , Jay DaRe a , Angelo
J. Castellino a , James M. Fujitaki a , Ross Dixon a , James R.
Appleman a & James B. Wiesner a
a Gensia, Inc. , 9390 Towne Centre Drive, San Diego, CA, 92121
Published online: 16 Aug 2006.
To cite this article: Mark D. Erion , Bheemarao G. Ugarkar , Jay DaRe , Angelo J. Castellino ,
James M. Fujitaki , Ross Dixon , James R. Appleman & James B. Wiesner (1997) Design, Synthesis
and Anticonvulsant Activity of the Potent Adenosine Kinase Inhibitor GP3269, Nucleosides and
Nucleotides, 16:7-9, 1013-1021, DOI: 10.1080/07328319708006124
To link to this article: http://dx.doi.org/10.1080/07328319708006124
PLEASE SCROLL DOWN FOR ARTICLE
Taylor & Francis makes every effort to ensure the accuracy of all the information (the
“Content”) contained in the publications on our platform. However, Taylor & Francis,
our agents, and our licensors make no representations or warranties whatsoever as to
the accuracy, completeness, or suitability for any purpose of the Content. Any opinions
and views expressed in this publication are the opinions and views of the authors,
and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content
should not be relied upon and should be independently verified with primary sources
of information. Taylor and Francis shall not be liable for any losses, actions, claims,
proceedings, demands, costs, expenses, damages, and other liabilities whatsoever
or howsoever caused arising directly or indirectly in connection with, in relation to or
arising out of the use of the Content.
This article may be used for research, teaching, and private study purposes. Any
substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing,
systematic supply, or distribution in any form to anyone is expressly forbidden. Terms
& Conditions of access and use can be found at http://www.tandfonline.com/page/
terms-and-conditions