A simple high-yielding synthesis of ferrocene-1,′-diylbis-(methyltrimethylammonium iodide)

Article abstract of DOI:10.1016/S0022-328X(96)06644-2

A new simple, high-yielding procedure has been developed for the synthesis of ferrocene-1,1′-diylbis(methyltrimethytammonium iodide) 2. Ferrocene is dilithiated using n-butyllithium/TMEDA and then reacted with Eschenmoser's salt to form the bis(dimethylaminomethyl) derivative 6 in good yield. Treatment with iodomethane gives rise to the corresponding ammonium salt 2 in excellent yield. Reaction of this bis-ammonium salt with sodium phenoxide affords the 1,1′-bis(phenoxymethyl) compound 10.