Synthesis of optically active diastereomers of a nonproteic neurotrophic mimetic

Article abstract of DOI:10.1016/0040-4020(96)00916-7

The four diastereomers 3, elongated analogues of perhydroretinol, are synthesized starting from both optically pure 3-bromo-2-methyl-1-propanol enantiomers. All exhibit neurotrophic activity on cultured neuronal cells derived from fetal rat cerebral hemispheres.