Tetrahedron p. 1557 - 1576 (1997)
Update date:2022-08-03
Topics:
Huffman, John W.
Lainton, Julia A.H.
Banner, W. Kenneth
Duncan Jr., Sammy G.
Jordan, Robert D.
Yu, Shu
Dai, Dong
Martin, Billy R.
Wiley, Jenny L.
Compton, David R.
The synthesis of both side chain epimers of 1'- (4), 2'- (5), 3'-methyl- (6) and 4'-methyl-Δ8-tetrahydrocannobinol (7) has been carried out. The synthetic approach entailed the acid catalyzed condensation of the appropriate substituted resorcinol with menthadienol to provide the Δ8-THC analogue. Both isomers of 1'- (4) and 2'-Δ8-THC (5) were more potent than Δ8-THC, both in vitro and in vivo. The 3'-methyl isomers (6) were approximately equal in potency to Δ8-THC, and 4'-methyl-Δ8-THC was less potent. There was relatively little difference in potency between the epimers of 4, 5, and 6.
View MoreSuZhou Ascepion Pharmaceuticals, Inc.(expird)
Contact:0512-86881668
Address:Building C,68Xingqing Road,Suzhou,China.
Hangzhou Bayee Chemical Co.,Ltd.
Contact:+86-571-86990109
Address:No.380, Jiangnan Auenue, Binjiang District, Hangzhou, China
Hangzhou GreenCo Science & Technology Co., Ltd.
Contact:86-571-88257303
Address:1713 Room,Jingui Building,Gudun Road,Xihu District,Hangzhou,China
website:https://www.sinoshiny.com/products
Contact:+86-20-62802632;62802633
Address:Room 330 GIGCAS Building,No.511 Kehua Street,Tianhe District
Contact:+86-158-05817090
Address:ROOM 9F, FLAT 2, GUODU DEVELOPING BLDG, No.182, ZHAOHUI ROAD
Doi:10.1021/ja963195c
(1997)Doi:10.1016/S0040-4020(96)01181-7
(1997)Doi:10.1039/DT9940002591
(1994)Doi:10.1016/S0040-4039(96)02427-6
(1997)Doi:10.1016/j.tetlet.2019.05.006
(2019)Doi:10.1021/jacs.5b12318
(2016)
