Bioorganic and Medicinal Chemistry Letters p. 1497 - 1500 (1997)
Update date:2022-07-30
Topics: Inhibitor Thrombin Noncovalent
Sanderson, Philip E. J.
Dona, L. Dyer
Naylor-Olsen, Adel M.
Vacca, Joseph P.
Gardell, Steven J.
Lewis, S. Dale
Lucas Jr., Bobby J.
Lyle, Elizabeth A.
Lynch Jr., Joseph J.
Mulichak, Anne M.
L-373,890, a highly selective and efficacious pyridinone acetamide thrombin inhibitor was designed using a combination of X-ray crystallography, molecular modeling and empirical structure optimization.
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