Chemical and Pharmaceutical Bulletin p. 36 - 42 (1997)
Update date:2022-08-03
Topics:
Nagasaka, Tatsuo
Imai, Tomoko
The chiral pyrrolidine derivatives, 4-(hydroxymethyl)-3- azabicyclo[3.1.0]hexan-2-ones (10 and 11) and 5,5-disubstituted 2- pyrrolidinones (20, 21 and 22), were synthesized starting from (S)- pyroglutamic acid and absolute configuration determination was made based on the 1H-NMR spectra of the bicyclic lactam intermediates.
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