Journal of Heterocyclic Chemistry p. 1959 - 1966 (1996)
Update date:2022-08-03
Topics:
Rosowsky, Andre
Mota, Clara E.
Queener, Sherry F.
Five previously undescribed trimetrexate analogues with bulky 2'-bromo substitution on the phenyl ring were synthesized in order to assess the effect of this structure modification on dihydrofolate reductase inhibition. Condensation of 2-[2-(2-bromo-3,4,5
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