Journal of Heterocyclic Chemistry p. 57 - 63 (1997)
Update date:2022-08-03
Topics:
Kim, Dong Chan
Yoo, Kyung Ho
Shin, Kye Jung
Park, Sang Woo
Kim, Dong Jin
The pKa's of several thiazole heterocyclic compounds have been determined and represent products with significantly high values. Because of their high basicities, sometimes these compounds were able to act as not only nucleophiles but also strong organic bases. 4-Substituted-3-methyl-2-methylimino-Δ4-thiazolines 5a-d reacted with ethyl bromoacetate in refluxing benzene, giving the corresponding N-alkylated salts 8a-d, while the products obtained from the reaction with 2-bromoacetophenone in the presence of base were pyrrolothiazines 10b-d.
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(1997)