Simple methods for the preparation of protected derivatives of D-allo- and L-allo-threonine

Article abstract of DOI:10.1016/S0040-4039(96)02297-6

Practical syntheses of protected derivatives of the non-proteinogenic allo-threonines are described. The key step is enzymatic resolution of threonine diastereomers, produced on controlled epimerization of the α-carbon atom. The protected allo-threonines are obtained in good overall yield and can be used in standard peptide synthesis protocols.