Bioorganic and Medicinal Chemistry Letters p. 739 - 744 (1997)
Update date:2022-07-31
Topics:
Chambers
Marfat
Cheng
Cohan
Damon
Duplantier
Hibbs
Jenkinson
Johnson
Kraus
Pettipher
Salter
Shirley
Umland
Tumor necrosis factor-α (TNF-α) has been implicated as a key mediator in the progression of rheumatoid arthritis. Inhibitors of phosphodiesterase IV (PDE IV) have been shown to inhibit the production of TNF-α by elevating intracellular levels of cyclic adenosine monophosphate (cAMP). Our efforts in a series of biarylcarboxamides have led to the identification of 8j (CP-353,164) as a potent inhibitor of PDE IV and TNF-α production.
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