Design of peptides with α,β-dehydro-residues: Syntheses, crystal structures and molecular conformations of two δPhe-Trp containing peptides

Article abstract of DOI:10.1016/S0022-2860(03)00173-X

The ΔPhe-Trp is a newly designed moiety that was found inducing a unique conformation in peptides. The peptides Boc-L-Val-ΔPhe-L-Trp-OCH₃ (I) and Boc-L-Leu-ΔPhe-L-Trp-OCH₃ (II) were synthesized by azlactone method in solution phase.