Peptide α-keto ester, α-keto amide, and α-keto acid inhibitors of calpains and other cysteine protease

Article abstract of DOI:10.1021/jm00074a031

A series of dipeptidyl and tripeptidyl α-keto esters, α-keto amides, and α-keto acids having leucine in the P₂ position were synthesized and evaluated as inhibitors for the cysteine proteases calpain I, calpain II, cathepsin B, and papain. In g