Studies on total syntheses of antitumor styryllactones: Stereoselective total syntheses of (+)-goniofufurone, (+)-goniobutenolide A, and (-)-goniobutenolide B

Article abstract of DOI:10.1016/0040-4020(96)00296-7

A highly stereoselective aldol reaction of the aldehyde 11, derived from (+)-tricarbonyl(η⁶-2-trimethylsilylbenzaldehyde)chromium(0) complex (4), with 2-trimethylsilyloxyfuran afforded the γ-lactone derivative 13. The γ-lactone 13 was subsequently converted into three antitumor styryllactones, (+)-goniofufurone, (+)-goniobutenolide A, and (-)-goniobutenolide B.