Synthesis of novel L-series 2',3'-dideoxy-3'-hydroxy-methyl-nucleosides and a convenient method for the separation of nucleoside anomers

Article abstract of DOI:10.1080/07328319708002533

Photoinduced addition of methanol to 5(R)-(tert- butyldimethylsilyloxymethyl) -2(5H)-furan-2-one (derived from L-gulono-1,4- lactone) provided the photoadduct 5(R)-(tert-butyldimethylsiloxymethyl)- 4(S)-hydroxymethyl-tetrahydrofuran-2-one, which was converted into two L- series-2',3'-dideoxy-3'-hydroxymethyl-nucleosides. In addition, we describe a new method for the chromatographic separation of cytidine anomers using a N- 2-(4-nitrophenyl)ethyl carbamate derivative.

Full text of DOI:10.1080/07328319708002533

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Nucleosides and Nucleotides
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Synthesis of Novel L-Series 2′, 3′-
Dideoxy-3′-Hydroxy-Methyl-Nucleosides
and a Convenient Method for the
Separation of Nucleosede Anomers
Jayne H.M. Gould a & John Mann a
a Department of Chemistry , Reading University , Whiteknights,
Reading, RG6 6AD, UK
Published online: 20 Aug 2006.
To cite this article: Jayne H.M. Gould & John Mann (1997) Synthesis of Novel L-Series 2′, 3′-
Dideoxy-3′-Hydroxy-Methyl-Nucleosides and a Convenient Method for the Separation of Nucleosede
Anomers, Nucleosides and Nucleotides, 16:1-2, 193-213, DOI: 10.1080/07328319708002533
To link to this article: http://dx.doi.org/10.1080/07328319708002533
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