Diprotection of primary amines as N-substituted-2,5-bis[(triisopropylsilyl)oxy]pyrroles (BIPSOP)

Article abstract of DOI:10.1016/S0040-4039(97)00443-7

Primary amines are diprotected as their 2,5-bis[(triisopropylsilyl)oxy]pyrrole derivatives (BIPSOP). This protecting group is stable to strong bases such as organolithiums and alkoxides at 0°C and to temperatures up to about 150°C. Removal may be accomplished by a mild two step sequence.