Synthetic studies of antitumor macrolide laulimalide: Enantioselective synthesis of the C3-C14 segment by a catalytic hetero Diels-Alder strategy

Article abstract of DOI:10.1016/S0040-4039(97)00416-4

The C₃-C₁₄ segment of the novel antitumor agent laulimalide has been constructed enantioselectively by utilizing a catalytic asymmetric hetero Diels-Alder reaction of benzyloxyacetaldehyde and Danishefsky's diene followed by Ferrier rearrangement and asymmetric conjugate reaction as the key steps.