Condensed Thiazoles, II: Synthesis of 7-Substituted Thiazolo[4,5-d]pyrimidines as Possible Anti-HIV, Anticancer, and Antimicrobial Agents

Article abstract of DOI:10.1007/BF00844697

Some 3-substituted 2-thioxothiazolo[4,5-d]pyrimidin-7(6H)-ones(2a, b; 4) have been synthesized and converted to their 7-chloro (3, 5), 7-diethanolamino (6a, b), 7-bis(2-chloroethyl)amino (7), 7-azido (8), 7-amino (9), 7-hydrazino (10), 7-mercapto (11a, b), and 7-methylthio (12) derivatives. These compounds were evaluated for their in vitro antimicrobial, anti-HIV, and anticancer activities.