Bioorganic and Medicinal Chemistry Letters p. 2073 - 2076 (1996)
Update date:2022-08-03
Topics:
Murata, Yoshinori
Woodward, Richard M.
Miledi, Ricardo
Overman, Larry E.
(1,2,5,6-Tetrahydropyridine-4-yl)methylphosphinic acid (TPMPA, 1), which is synthesized in six steps from 3-butyn-1-ol, is the first γ-aminobutyric acid (GABA) receptor antagonist that shows strong selectivity for mammalian GABAc receptors. Copyright
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