The first selective antagonist for a GABAC receptor

DOI: 10.1016/0960-894X(96)00364-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2073 - 2076 (1996)

Update date:2022-08-03

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Authors:

Murata, Yoshinori

Woodward, Richard M.

Miledi, Ricardo

Overman, Larry E.

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Article abstract of DOI:10.1016/0960-894X(96)00364-2

(1,2,5,6-Tetrahydropyridine-4-yl)methylphosphinic acid (TPMPA, 1), which is synthesized in six steps from 3-butyn-1-ol, is the first γ-aminobutyric acid (GABA) receptor antagonist that shows strong selectivity for mammalian GABA_c receptors. Copyright

Full text of DOI:10.1016/0960-894X(96)00364-2

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