Crystal engineering for absolute asymmetric synthesis through the use of meta substituted aryl groups

DOI: 10.1016/S0040-4039(97)00615-1

Source and publish data:

Tetrahedron Letters p. 3135 - 3138 (1997)

Update date:2022-08-03

Topics:

Authors:

Wu, Lian-Chung

Cheer, Clair J.

Olovsson, Gunnar

Scheffer, John R.

Trotter, James

Wang, Sue-Lein

Liao, Fen-Ling

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Article abstract of DOI:10.1016/S0040-4039(97)00615-1

A significant tendency towards crystallization in chiral space groups has been found for 4-benzyloxy-2-pyridones whose phenyl groups are meta-substituted (m-Cl, m-Br, m-Me and m-OMe). Irradiation of single crystals of three of these materials leads to optically active p-lactam derivatives in high chemical and optical yields via an allowed disrotatory electrocyclization.

Full text of DOI:10.1016/S0040-4039(97)00615-1

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