Glycosylation of 2-thiouracil derivatives. A synthetic approach to 3- glycosyl-2,4-dioxypyrimidines

Article abstract of DOI:10.1080/07328319708001360

Reaction of 6-aryl-5-cyano-2-thiouracils 2a-d with glycosyl halides 4a,b under alkaline conditions gave the respective bisglycosylated derivatives 5a- h. However, their deacetylation with ammonia in methanol caused a cleavage of the S-glycosyl residue and gave the N-3 glycosylated analogues 6a-h.

Full text of DOI:10.1080/07328319708001360

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Glycosylation of 2-Thiouracil
Derivatives. A Synthetic Approach to
3-Glycosyl-2, 4-dioxypyrimidines
A. I. Khodair a , E. E. Ibrahim b & E. S. H. El Ashry c
a Department of Chemistry, Faculty of Education, Tanta
University, Kafer EL-Sheikh Branch, Tanta, Egypt
b Department of Chemistry, Faculty of Science, Suez Canal
University, Ismailia, Egypt
c Department of Chemistry, Faculty of Science, Alexandria
University, Alexandria, Egypt
Version of record first published: 21 Aug 2006
To cite this article: A. I. Khodair, E. E. Ibrahim & E. S. H. El Ashry (1997): Glycosylation of 2-
Thiouracil Derivatives. A Synthetic Approach to 3-Glycosyl-2, 4-dioxypyrimidines, Nucleosides and
Nucleotides, 16:4, 433-444
To link to this article: http://dx.doi.org/10.1080/07328319708001360
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