Synthesis of optically pure α-hydroxyglycine peptides

Article abstract of DOI:10.1016/S0040-4020(97)00429-8

Optically pure a-hydroxyglycine peptides can be prepared by enzymatic resolution of DL-α-(benzyloxy)glycine peptide eaters with subtilisin Carlsberg followed by hydrogenolysis of the benzyl protecting group. The DL-α-(benzyloxy)glycine peptide eaters were obtained from the corresponding serine derivatives via lead tetraacetate oxidation and reaction of the resulting electrophilic glycine equivalents with benzyl alcohol.