Novel and versatile synthesis of pyrrolidine type azasugars, DAB-1 and LAB-1, potent glucosidase inhibitors

DOI: 10.1016/S0040-4020(97)00445-6

Source and publish data:

Tetrahedron p. 7501 - 7508 (1997)

Update date:2022-07-29

Topics:

Authors:

Kim, Yong Jip

Kido, Masaru

Bando, Masahiko

Kitahara, Takeshi

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Article abstract of DOI:10.1016/S0040-4020(97)00445-6

Synthesis or glucosidase inhibitors, DAB-1 (1) and LAB-1 (2) from diethyl tartrate is described. The procedure afforded an epimerizable mixture of diastereomeric intermediates 8 and ent. 8, and opened the door not only to the selective synthesis or DAB-1 and LAB-1 but for giving various related analogs.

Full text of DOI:10.1016/S0040-4020(97)00445-6

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