Bioorganic and Medicinal Chemistry Letters p. 1359 - 1364 (1997)
Update date:2022-08-03
Topics:
Tamura, Susan Y.
Shamblin, Brian M.
Brunck, Terence K.
Ripka, William C.
Peptidomimetic derivatives featuring a P1-argininoyl heterocycle were designed. The preparation of two key building blocks containing benzoxazole or benzimidazole rings and their incorporation into thrombin and factor Xa specific sequences is described. The serine protease inhibitory activity of these targets was evaluated. Molecular modeling of two representative structures is presented.
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