A new synthesis of (E)-4-alkoxy-2-formylamino-3-butenoic acid derivatives utilizing 3-alkoxy-1-isocyano-1-lithiopropenes

Article abstract of DOI:10.1246/cl.1997.503

The title amino acid derivatives have been prepared in two steps from 3-alkoxy-1-isocyanopropenes. The key step is the alkoxycarbonylation of 3-alkoxy-1-isocyano-1-lithiopropenes with alkyl chloroformates to afford the corresponding 4-alkoxy-2-isocyano-3-