Addition of organozincate reagents to imines derived from (S)-1-phenylethylamine and ethyl (S)-valinate-synthesis of (S)-1-(2-pyridyl)alkylamines

Article abstract of DOI:10.1002/chem.19970030512

Triorganozincates were added to aliphatic aldimines derived from (S)-1-phenylethylamine and (S)-valine esters in the presence of boron trifluoride to give secondary amines with low diastereoselectivies. From mixed zincates, most alkyl groups (methyl, ethy