Solution phase combinatorial synthesis of arylpiperazines

DOI: 10.1016/S0040-4039(97)00831-9

Source and publish data:

Tetrahedron Letters p. 4091 - 4094 (1997)

Update date:2022-08-03

Topics:

Authors:

Neuville, Luc

Zhu, Jieping

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Article abstract of DOI:10.1016/S0040-4039(97)00831-9

A solution phase combinatorial synthesis of aryl piperazines 1 and 2 is described based on the S(N)Ar reaction and Schotten-Baumann acylation. The use of excess reagent is allowed and pure arylpiperazines 1 and 2 were obtained by simple acid/base washing.

Full text of DOI:10.1016/S0040-4039(97)00831-9

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