Tetrahedron Letters p. 4091 - 4094 (1997)
Update date:2022-08-03
Topics:
Neuville, Luc
Zhu, Jieping
A solution phase combinatorial synthesis of aryl piperazines 1 and 2 is described based on the S(N)Ar reaction and Schotten-Baumann acylation. The use of excess reagent is allowed and pure arylpiperazines 1 and 2 were obtained by simple acid/base washing.
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Doi:10.1021/jo01258a088
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