Synthetic studies toward potent cytotoxic agent amphidinolide B: Synthesis of the entire Cl-C13 moiety of the bottom half

Article abstract of DOI:10.1246/cl.1997.565

Sharpless asymmetric dihydroxylation and Nozaki-Hiyama-Kishi's Cr(II)-mediated coupling between an α-alkoxyaldehyde and a vinyl iodide are the key steps in the stereoselective synthesis of the entire C1-C13 segment of the bottom-half of amphidinolide B.