Bioorganic and Medicinal Chemistry Letters p. 1483 - 1486 (2003)
Update date:2022-08-03
Topics:
Miller, William H.
Manley, Peter J.
Cousins, Russell D.
Erhard, Karl F.
Heerding, Dirk A.
Kwon, Chet
Ross, Stephen T.
Samanen, James M.
Takata, Dennis T.
Uzinskas, Irene N.
Yuan, Catherine C. K.
Haltiwanger, R. Curtis
Gress, Catherine J.
Lark, Michael W.
Hwang, Shing-Mei
James, Ian E.
Rieman, David J.
Willette, Robert N.
Yue, Tian-Li
Azzarano, Leonard M.
Salyers, Kevin L.
Smith, Brian R.
Ward, Keith W.
Johanson, Kyung O.
Huffman, William F.
In our continuing efforts to identify small molecule vitronectin receptor antagonists, we have discovered a series of phenylbutyrate derivatives, exemplified by 16, which have good potency and excellent oral bioavailability (approximately 100% in rats). T
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