Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 3. Enhancing activity by imposing conformational restriction in the C-4'' side chain

Article abstract of DOI:10.1016/S0960-894X(98)00746-X

The preparation and biological evaluation of a series of benzo[b]thiophene diamine thrombin inhibitors possessing conformationally restricted C-4'' linkers are reported. Compared to the parent compounds 1a/b, the unsaturated derivatives 3a/b exhibited a m