Diastereoselective azomethine ylide cycloadditions to unsaturated, chiral bicyclic lactams

DOI: 10.1016/S0040-4039(00)92506-1

Source and publish data:

Tetrahedron Letters p. 3575 - 3578 (1992)

Update date:2022-08-03

Topics: Regioselectivity Yield NMR spectroscopy Chiral HPLC Enantioselectivity Deprotonation Diastereoselective X-ray crystallography Stereocontrol Solvent Effects Cycloaddition Chiral Auxiliary Tautomerization Lewis Acid Catalysis 1,3-Dipolar Cycloaddition Azomethine Ylide Unsaturated Transition state

Authors:

Fray Fray

Meyers Meyers

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Article abstract of DOI:10.1016/S0040-4039(00)92506-1

The levels of diastereoselection resulting from the 1,3-dipolar cycloaddition of chiral and achiral ylides (2(a-c) to chiral, unsaturated bicyclic lactams 1(a-f) are described in terms of steric factors.

Full text of DOI:10.1016/S0040-4039(00)92506-1

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