Asymmetric synthesis of the alkaloid 2,6-disubstituted piperidin-3-ols, (-)-cassine and (+)-spectaline

Article abstract of DOI:10.1016/S0040-4039(00)73860-3

The asymmetric total synthesis of (-)-cassine (1) and (+)-spectaline (2) was achieved by starting with both enantiomers of the homochiral 3-oxygenated 2,6-cis-disubstituted piperidine 3.